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Type Boys Girls Stage 1 (prepubertal) No sexual growth No sexual growth Testes enlarge Breast budding, first pubic hair Stage 2 Body odor Body odor Height spurt Penis enlarges Breasts enlarge Stage 3 First pubic hair Pubic hair darkens, turns into curlier Ejaculation (might embody wet goals) Vaginal discharge Continued enlargement of testes and penis Onset of menstruation Stage 4 Penis and scrotum deepen in colour Nipple becomes distinct from surrounding Pubic hair curlier and coarser areola Height spurt Pelvis begins to widen Male breast growth (short-term) Pubic hair extends to inner thighs Pubic hair extends to internal thighs Stage 5 (Fully mature Increase in top slows, then stops Increase in peak slows, then stops adult) Increased muscle mass Deposition of fat in hips, buttocks, thighs, and breasts Table 1: Changes that take place in human men and women as puberty progresses. Combination therapy with interferon and ribavirin is more practical in hepatitis C. 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