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Detecting changes in fnancial safety: creating evidence for coverage in Estonia. All Exp Med Surg Exp Proc Surg Exp Surg Studies (N) 14 27 2 1 18 9 1 25 97 a Location North America 8 9 zero 1 7 0 zero zero 25 Europe 5 11 2 0 four 7 1 15 forty five Asia zero 3 zero zero 7 2 zero 8 20 Middle East 1 four 0 zero zero 0 0 1 6 South America zero zero zero 0 0 0 0 1 1 Decade of 1985 to1995 2 6 1 0 0 0 0 zero 9 Publication 1996 to 2005 5 8 1 zero 3 2 zero 10 29 2006 to 2016 7 13 0 1 15 7 1 15 fifty nine Study Quality Good 2 2 zero zero 4 2 zero eight 18 Fair 5 7 zero 1 four three zero 7 27 Poor 7 18 2 0 10 four 1 10 52 Participants Randomized 1,159 2,570 114 20 1,171 962 181 three,002 9,179 Note: None of the included research in contrast treatment with procedure or procedure with expectant administration Exp = expectant administration; Med = medical; N = quantity; Proc = procedural; Surg = surgical aIncludes research performed in the United States, Canada, and Cuba. 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